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5-Aminolevulinate Synthase Catalysis: The Catcher in Heme Biosynthesis
5-Aminolevulinate (ALA) synthase (ALAS), a homodimeric pyridoxal-5’-phosphate (PLP)-dependent enzyme, catalyzes the first step of heme biosynthesis in metazoa, fungi and α-proteobacteria. In this review, we focus on the advances made in unraveling the mechanism of the ALAS-catalyzed reaction during...
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| Publicado en: | Mol Genet Metab |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6908770/ https://ncbi.nlm.nih.gov/pubmed/31345668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2019.06.003 |
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