Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Genomic amplification of the oncogene MYCN is a major driver in the development of high-risk neuroblastoma, a pediatric cancer with poor prognosis. Given the challenge in targeting MYCN directly for therapy, we sought to identify MYCN-dependent metabolic vulnerabilities that can be targeted therapeu...

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Vydáno v:Oncogene
Hlavní autoři: Alptekin, Ahmet, Ye, Bingwei, Yu, Yajie, Poole, Candace J., van Riggelen, Jan, Zha, Yunhong, Ding, Han-Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908766/
https://ncbi.nlm.nih.gov/pubmed/31444411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0967-3
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