Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography

BACKGROUND: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of currently known anticancer drugs. High-grade brain tumors often possess a disrupted bl...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:EJNMMI Res
Κύριοι συγγραφείς: Wulkersdorfer, Beatrix, Bauer, Martin, Karch, Rudolf, Stefanits, Harald, Philippe, Cécile, Weber, Maria, Czech, Thomas, Menet, Marie-Claude, Declèves, Xavier, Hainfellner, Johannes A., Preusser, Matthias, Hacker, Marcus, Zeitlinger, Markus, Müller, Markus, Langer, Oliver
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Springer Berlin Heidelberg 2019
Θέματα:
Original Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908538/
https://ncbi.nlm.nih.gov/pubmed/31832814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-019-0581-y
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