Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography

BACKGROUND: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of currently known anticancer drugs. High-grade brain tumors often possess a disrupted bl...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Wulkersdorfer, Beatrix, Bauer, Martin, Karch, Rudolf, Stefanits, Harald, Philippe, Cécile, Weber, Maria, Czech, Thomas, Menet, Marie-Claude, Declèves, Xavier, Hainfellner, Johannes A., Preusser, Matthias, Hacker, Marcus, Zeitlinger, Markus, Müller, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908538/
https://ncbi.nlm.nih.gov/pubmed/31832814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-019-0581-y
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