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Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[(11)C]verapamil in elderly vs. young subjects
AIMS: The efflux transporter P‐glycoprotein (ABCB1) acts at the blood–brain barrier (BBB) to restrict the distribution of many different drugs from blood to the brain. Previous data suggest an age‐associated decrease in the expression and function of ABCB1 at the BBB. In the present study, we invest...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555869/ https://ncbi.nlm.nih.gov/pubmed/28401570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13301 |
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