Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[(11)C]verapamil PET study

As P-glycoprotein (Pgp) inhibition at the blood–brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron emission tomography (PET) scans with the Pgp substrate (R)-[(11)C]verapamil in five healthy volunteers during continuous intravenous tariquidar...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Bauer, Martin, Karch, Rudolf, Zeitlinger, Markus, Philippe, Cécile, Römermann, Kerstin, Stanek, Johann, Maier-Salamon, Alexandra, Wadsak, Wolfgang, Jäger, Walter, Hacker, Marcus, Müller, Markus, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420865/
https://ncbi.nlm.nih.gov/pubmed/25669913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.19
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