P-glycoprotein mediated interaction between (R)-[(11)C]verapamil and tariquidar at the human blood-brain barrier studied with positron emission tomography, a comparison with rat data

Using positron emission tomography (PET) imaging we assessed in vivo the interaction between a microdose of (R)-[(11)C]verapamil, a P-glycoprotein (Pgp) substrate, and escalating doses of the Pgp inhibitor tariquidar (3, 4, 6 and 8 mg/kg) at the blood-brain barrier (BBB) of healthy human subjects. W...

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Main Authors: Bauer, Martin, Zeitlinger, Markus, Karch, Rudolf, Matzneller, Peter, Stanek, Johann, Jäger, Walter, Böhmdorfer, Michaela, Wadsak, Wolfgang, Mitterhauser, Markus, Bankstahl, Jens P., Löscher, Wolfgang, Koepp, Matthias, Müller, Markus, Langer, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685270/
https://ncbi.nlm.nih.gov/pubmed/22166851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.217
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