The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) is implicated in vascular diseases such as pulmonary arterial hypertension (PAH). Here, we showed that the transcription factor ATOH8 was a direct target of SMAD1/5 and was induced in a manner dependent on BMP but ind...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Morikawa, Masato, Mitani, Yoshihide, Holmborn, Katarina, Kato, Taichi, Koinuma, Daizo, Maruyama, Junko, Vasilaki, Eleftheria, Sawada, Hirofumi, Kobayashi, Mai, Ozawa, Takayuki, Morishita, Yasuyuki, Bessho, Yasumasa, Maeda, Shingo, Ledin, Johan, Aburatani, Hiroyuki, Kageyama, Ryoichiro, Maruyama, Kazuo, Heldin, Carl-Henrik, Miyazono, Kohei
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908447/
https://ncbi.nlm.nih.gov/pubmed/31719172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay4430
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