The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) is implicated in vascular diseases such as pulmonary arterial hypertension (PAH). Here, we showed that the transcription factor ATOH8 was a direct target of SMAD1/5 and was induced in a manner dependent on BMP but ind...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Signal
Auteurs principaux: Morikawa, Masato, Mitani, Yoshihide, Holmborn, Katarina, Kato, Taichi, Koinuma, Daizo, Maruyama, Junko, Vasilaki, Eleftheria, Sawada, Hirofumi, Kobayashi, Mai, Ozawa, Takayuki, Morishita, Yasuyuki, Bessho, Yasumasa, Maeda, Shingo, Ledin, Johan, Aburatani, Hiroyuki, Kageyama, Ryoichiro, Maruyama, Kazuo, Heldin, Carl-Henrik, Miyazono, Kohei
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908447/
https://ncbi.nlm.nih.gov/pubmed/31719172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay4430
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires