The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) is implicated in vascular diseases such as pulmonary arterial hypertension (PAH). Here, we showed that the transcription factor ATOH8 was a direct target of SMAD1/5 and was induced in a manner dependent on BMP but ind...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Signal
Main Authors: Morikawa, Masato, Mitani, Yoshihide, Holmborn, Katarina, Kato, Taichi, Koinuma, Daizo, Maruyama, Junko, Vasilaki, Eleftheria, Sawada, Hirofumi, Kobayashi, Mai, Ozawa, Takayuki, Morishita, Yasuyuki, Bessho, Yasumasa, Maeda, Shingo, Ledin, Johan, Aburatani, Hiroyuki, Kageyama, Ryoichiro, Maruyama, Kazuo, Heldin, Carl-Henrik, Miyazono, Kohei
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908447/
https://ncbi.nlm.nih.gov/pubmed/31719172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay4430
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares