BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation. Osteocytes or osteoblasts express receptor activator of nuclear factor κ-B ligand (Rankl) or osteoprotegerin (Opg) to promote or inhibit osteoclastogenesis, r...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Yahiro, Yuhei, Maeda, Shingo, Morikawa, Masato, Koinuma, Daizo, Jokoji, Go, Ijuin, Toshiro, Komiya, Setsuro, Kageyama, Ryoichiro, Miyazono, Kohei, Taniguchi, Noboru
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463266/
https://ncbi.nlm.nih.gov/pubmed/32923015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00106-0
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