BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation. Osteocytes or osteoblasts express receptor activator of nuclear factor κ-B ligand (Rankl) or osteoprotegerin (Opg) to promote or inhibit osteoclastogenesis, r...

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Publicado en:Bone Res
Autores principales: Yahiro, Yuhei, Maeda, Shingo, Morikawa, Masato, Koinuma, Daizo, Jokoji, Go, Ijuin, Toshiro, Komiya, Setsuro, Kageyama, Ryoichiro, Miyazono, Kohei, Taniguchi, Noboru
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463266/
https://ncbi.nlm.nih.gov/pubmed/32923015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00106-0
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