BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation. Osteocytes or osteoblasts express receptor activator of nuclear factor κ-B ligand (Rankl) or osteoprotegerin (Opg) to promote or inhibit osteoclastogenesis, r...

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Enregistré dans:
Détails bibliographiques
Publié dans:Bone Res
Auteurs principaux: Yahiro, Yuhei, Maeda, Shingo, Morikawa, Masato, Koinuma, Daizo, Jokoji, Go, Ijuin, Toshiro, Komiya, Setsuro, Kageyama, Ryoichiro, Miyazono, Kohei, Taniguchi, Noboru
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463266/
https://ncbi.nlm.nih.gov/pubmed/32923015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00106-0
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