BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation. Osteocytes or osteoblasts express receptor activator of nuclear factor κ-B ligand (Rankl) or osteoprotegerin (Opg) to promote or inhibit osteoclastogenesis, r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bone Res
Prif Awduron: Yahiro, Yuhei, Maeda, Shingo, Morikawa, Masato, Koinuma, Daizo, Jokoji, Go, Ijuin, Toshiro, Komiya, Setsuro, Kageyama, Ryoichiro, Miyazono, Kohei, Taniguchi, Noboru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463266/
https://ncbi.nlm.nih.gov/pubmed/32923015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00106-0
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