The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) is implicated in vascular diseases such as pulmonary arterial hypertension (PAH). Here, we showed that the transcription factor ATOH8 was a direct target of SMAD1/5 and was induced in a manner dependent on BMP but ind...

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Vydáno v:Sci Signal
Hlavní autoři: Morikawa, Masato, Mitani, Yoshihide, Holmborn, Katarina, Kato, Taichi, Koinuma, Daizo, Maruyama, Junko, Vasilaki, Eleftheria, Sawada, Hirofumi, Kobayashi, Mai, Ozawa, Takayuki, Morishita, Yasuyuki, Bessho, Yasumasa, Maeda, Shingo, Ledin, Johan, Aburatani, Hiroyuki, Kageyama, Ryoichiro, Maruyama, Kazuo, Heldin, Carl-Henrik, Miyazono, Kohei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908447/
https://ncbi.nlm.nih.gov/pubmed/31719172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay4430
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