Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology

Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent meta-analysis demonstrated the potential link between ALDH2*2 mutation and Alzheimer’s Disease (AD). Other studies have linked chronic alcohol cons...

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Publicat a:Acta Neuropathol Commun
Autors principals: Joshi, Amit U., Van Wassenhove, Lauren D., Logas, Kelsey R., Minhas, Paras S., Andreasson, Katrin I., Weinberg, Kenneth I., Chen, Che-Hong, Mochly-Rosen, Daria
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907112/
https://ncbi.nlm.nih.gov/pubmed/31829281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0839-7
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