A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing

G-protein coupled receptors (GPCRs) are central to how mammalian cells sense and respond to chemicals. Mammalian olfactory receptors (ORs), the largest family of GPCRs, mediate the sense of smell through activation by small molecules, though for most bonafide ligands have not been identified. Here,...

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Udgivet i:Cell Syst
Main Authors: Jones, Eric M., Jajoo, Rishi, Cancilla, Daniel, Lubock, Nathan B., Wang, Jeff, Satyadi, Megan, Chong, Rockie, de March, Claire, Bloom, Joshua S., Matsunami, Hiroaki, Kosuri, Sriram
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907015/
https://ncbi.nlm.nih.gov/pubmed/30904378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.02.009
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