A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing

G-protein coupled receptors (GPCRs) are central to how mammalian cells sense and respond to chemicals. Mammalian olfactory receptors (ORs), the largest family of GPCRs, mediate the sense of smell through activation by small molecules, though for most bonafide ligands have not been identified. Here,...

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Publicado no:Cell Syst
Main Authors: Jones, Eric M., Jajoo, Rishi, Cancilla, Daniel, Lubock, Nathan B., Wang, Jeff, Satyadi, Megan, Chong, Rockie, de March, Claire, Bloom, Joshua S., Matsunami, Hiroaki, Kosuri, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907015/
https://ncbi.nlm.nih.gov/pubmed/30904378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.02.009
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