Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation

Metabolism is a critical regulator of cell fate determination. Recently, the significance of metabolic reprogramming in environmental adaptation during tumorigenesis has attracted much attention in cancer research. Recurrent mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes have been iden...

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Publicat a:Sci Rep
Autors principals: Fujiwara, Hiroaki, Tateishi, Keisuke, Misumi, Kento, Hayashi, Akimasa, Igarashi, Kaori, Kato, Hiroyuki, Nakatsuka, Takuma, Suzuki, Nobumi, Yamamoto, Keisuke, Kudo, Yotaro, Hayakawa, Yoku, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Kogure, Hirofumi, Nakai, Yosuke, Isayama, Hiroyuki, Hasegawa, Kiyoshi, Fukayama, Masashi, Soga, Tomoyoshi, Koike, Kazuhiko
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906335/
https://ncbi.nlm.nih.gov/pubmed/31827136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55211-w
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