Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation

Metabolism is a critical regulator of cell fate determination. Recently, the significance of metabolic reprogramming in environmental adaptation during tumorigenesis has attracted much attention in cancer research. Recurrent mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes have been iden...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Fujiwara, Hiroaki, Tateishi, Keisuke, Misumi, Kento, Hayashi, Akimasa, Igarashi, Kaori, Kato, Hiroyuki, Nakatsuka, Takuma, Suzuki, Nobumi, Yamamoto, Keisuke, Kudo, Yotaro, Hayakawa, Yoku, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Kogure, Hirofumi, Nakai, Yosuke, Isayama, Hiroyuki, Hasegawa, Kiyoshi, Fukayama, Masashi, Soga, Tomoyoshi, Koike, Kazuhiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906335/
https://ncbi.nlm.nih.gov/pubmed/31827136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55211-w
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