CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity

OBJECTIVE: Metabolic reprogramming of tumor cells that allows for adaptation to their local environment is a hallmark of cancer. Interestingly, obesity- and nonalcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) mouse models commonly exhibit strong steatosis in tumor cells as seen...

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Pubblicato in:Gut
Autori principali: Fujiwara, Naoto, Nakagawa, Hayato, Enooku, Kenichiro, Kudo, Yotaro, Hayata, Yuki, Nakatsuka, Takuma, Tanaka, Yasuo, Tateishi, Ryosuke, Hikiba, Yohko, Misumi, Kento, Tanaka, Mariko, Hayashi, Akimasa, Shibahara, Junji, Fukayama, Masashi, Arita, Junichi, Hasegawa, Kiyoshi, Hirschfield, Hadassa, Hoshida, Yujin, Hirata, Yoshihiro, Otsuka, Motoyuki, Tateishi, Keisuke, Koike, Kazuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039238/
https://ncbi.nlm.nih.gov/pubmed/29437870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-315193
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