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Tension in fibrils suppresses their enzymatic degradation – a molecular mechanism for ‘Use it or Lose it’

Tissue homeostasis depends on a balance of synthesis and degradation of constituent proteins, with use of a given protein potentially regulating its turnover. Extracellular matrix (ECM) is predominantly composed of fibrillar collagens that exhibit tension-sensitive degradation, which we review here...

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Bibliografski detalji
Izdano u:Matrix Biol
Glavni autori: Saini, Karanvir, Cho, Sangkyun, Dooling, Lawrence J., Discher, Dennis E.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906264/
https://ncbi.nlm.nih.gov/pubmed/31201857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2019.06.001
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