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The Catalytic M-center of Copper Monooxygenases probed by Rational Design. Effects of Selenomethionine and Histidine Substitution on Structure and Reactivity.

The M-centers of the mononuclear monooxygenases peptidylglycine monooxygenase (PHM) and dopamine β-monooxygenase (DBM) bind and activate dioxygen on route to substrate hydroxylation. Recently we reported the rational design of a protein-based model wherein the CusF metallochaperone was repurposed vi...

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Dettagli Bibliografici
Pubblicato in:Biochemistry
Autori principali: Alwan, Katherine B., Welch, Evan F., Blackburn, Ninian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905645/
https://ncbi.nlm.nih.gov/pubmed/31626532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00823
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