The Catalytic Copper of Peptidylglycine α-Hydroxylating Monooxygenase also Plays a Critical Structural Role

Many bioactive peptides require amidation of their carboxy terminus to exhibit full biological activity. Peptidylglycine α-hydroxylating monooxygenase (PHM; EC 1.14.17.3), the enzyme that catalyzes the first of the two steps of this reaction, is composed of two domains, each of which binds one coppe...

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Main Authors: Siebert, Xavier, Eipper, Betty A., Mains, Richard E., Prigge, Sean T., Blackburn, Ninian J., Amzel, L. Mario
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2005
Assuntos:
Proteins
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366827/
https://ncbi.nlm.nih.gov/pubmed/16100265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.066100
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