Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase

The oncogenic fusion protein RUNX1-ETO is a product of the t(8;21) translocation and consists of the hematopoietic transcriptional master regulator RUNX1 and the repressor ETO. RUNX1-ETO is found in 10–15% of acute myeloid leukemia and interferes with the expression of genes that are essential for m...

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Опубликовано в: :PLoS One
Главные авторы: Schoenherr, Caroline, Wohlan, Katharina, Dallmann, Iris, Pich, Andreas, Hegermann, Jan, Ganser, Arnold, Hilfiker-Kleiner, Denise, Heidenreich, Olaf, Scherr, Michaela, Eder, Matthias
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905530/
https://ncbi.nlm.nih.gov/pubmed/31826021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225977
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