Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis

A microbe’s ecological niche and biotechnological utility are determined by its specific set of co-evolved metabolic pathways. The acquisition of new pathways, through horizontal gene transfer or genetic engineering, can have unpredictable consequences. Here we show that two different pathways for c...

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Udgivet i:Mol Microbiol
Main Authors: Close, Dan M., Cooper, Connor J., Wang, Xingyou, Chirania, Payal, Gupta, Madhulika, Ossyra, John R., Giannone, Richard J., Engle, Nancy, Tschaplinski, Timothy J., Smith, Jeremy C., Hedstrom, Lizbeth, Parks, Jerry M., Michener, Joshua K.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904512/
https://ncbi.nlm.nih.gov/pubmed/31532038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14393
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