Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis

A microbe’s ecological niche and biotechnological utility are determined by its specific set of co-evolved metabolic pathways. The acquisition of new pathways, through horizontal gene transfer or genetic engineering, can have unpredictable consequences. Here we show that two different pathways for c...

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Détails bibliographiques
Publié dans:Mol Microbiol
Auteurs principaux: Close, Dan M., Cooper, Connor J., Wang, Xingyou, Chirania, Payal, Gupta, Madhulika, Ossyra, John R., Giannone, Richard J., Engle, Nancy, Tschaplinski, Timothy J., Smith, Jeremy C., Hedstrom, Lizbeth, Parks, Jerry M., Michener, Joshua K.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904512/
https://ncbi.nlm.nih.gov/pubmed/31532038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14393
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