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Effective use of a horizontally-transferred pathway for dichloromethane catabolism requires post–transfer refinement

When microbes acquire new abilities through horizontal gene transfer, the genes and pathways must function under conditions with which they did not coevolve. If newly-acquired genes burden the host, their utility will depend on further evolutionary refinement of the recombinant strain. We used labor...

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Veröffentlicht in:eLife
Hauptverfasser: Michener, Joshua K, Camargo Neves, Aline A, Vuilleumier, Stéphane, Bringel, Françoise, Marx, Christopher J
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271186/
https://ncbi.nlm.nih.gov/pubmed/25418043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04279
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