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Dehalogenation of Dichloromethane by Dichloromethane Dehalogenase/Glutathione S-Transferase Leads to Formation of DNA Adducts

Formation of DNA adducts following conversion of dichloromethane by bacterial dichloromethane dehalogenase/glutathione S-transferase was demonstrated. Adducts included dichloromethane carbon and glutathione sulfur atoms. A reaction with DNA occurred preferentially at guanine bases. Increased DNA deg...

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Autors principals: Kayser, Martin F., Vuilleumier, Stéphane
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC95400/
https://ncbi.nlm.nih.gov/pubmed/11489877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.17.5209-5212.2001
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