Dehalogenation of Dichloromethane by Dichloromethane Dehalogenase/Glutathione S-Transferase Leads to Formation of DNA Adducts

Formation of DNA adducts following conversion of dichloromethane by bacterial dichloromethane dehalogenase/glutathione S-transferase was demonstrated. Adducts included dichloromethane carbon and glutathione sulfur atoms. A reaction with DNA occurred preferentially at guanine bases. Increased DNA deg...

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Pubblicato in:	J Bacteriol
Autori principali:	Kayser, Martin F., Vuilleumier, Stéphane
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Enzymes and Proteins
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11489877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.17.5209-5212.2001
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