Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation

Leigh syndrome is a devastating mitochondrial disease for which there are no proven therapies. We previously showed that breathing chronic, continuous hypoxia can prevent and even reverse neurological disease in the Ndufs4 knockout (KO) mouse model of complex I (CI) deficiency and Leigh syndrome. He...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Jain, Isha H., Zazzeron, Luca, Goldberger, Olga, Marutani, Eizo, Wojtkiewicz, Gregory R., Ast, Tslil, Wang, Hong, Schleifer, Grigorij, Stepanova, Anna, Brepoels, Kathleen, Schoonjans, Luc, Carmeliet, Peter, Galkin, Alexander, Ichinose, Fumito, Zapol, Warren M., Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903907/
https://ncbi.nlm.nih.gov/pubmed/31402314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.07.006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados