Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation

Leigh syndrome is a devastating mitochondrial disease for which there are no proven therapies. We previously showed that breathing chronic, continuous hypoxia can prevent and even reverse neurological disease in the Ndufs4 knockout (KO) mouse model of complex I (CI) deficiency and Leigh syndrome. He...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Metab
Hauptverfasser: Jain, Isha H., Zazzeron, Luca, Goldberger, Olga, Marutani, Eizo, Wojtkiewicz, Gregory R., Ast, Tslil, Wang, Hong, Schleifer, Grigorij, Stepanova, Anna, Brepoels, Kathleen, Schoonjans, Luc, Carmeliet, Peter, Galkin, Alexander, Ichinose, Fumito, Zapol, Warren M., Mootha, Vamsi K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903907/
https://ncbi.nlm.nih.gov/pubmed/31402314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.07.006
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge