An engineered enzyme that targets circulating lactate to alleviate intracellular NADH/NAD(+) imbalance

An elevated intracellular NADH/NAD(+) ratio, or “reductive stress”, has been associated with multiple diseases, including disorders of the mitochondrial electron transport chain (ETC). As the intracellular NADH/NAD(+) ratio can be in near equilibrium with the circulating lactate/pyruvate ratio, we h...

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Gepubliceerd in:Nat Biotechnol
Hoofdauteurs: Patgiri, Anupam, Skinner, Owen S., Miyazaki, Yusuke, Schleifer, Grigorij, Marutani, Eizo, Shah, Hardik, Sharma, Rohit, Goodman, Russell P., To, Tsz-Leung, Bao, Xiaoyan Robert, Ichinose, Fumito, Zapol, Warren M., Mootha, Vamsi K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135927/
https://ncbi.nlm.nih.gov/pubmed/31932725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0377-7
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