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Complementation of mitochondrial electron transport chain by manipulation of the NAD(+)/NADH ratio

A decline in electron transport chain (ETC) activity is associated with many human diseases. Although diminished mitochondrial ATP production is recognized as a source of pathology, the contribution of the associated reduction in the ratio of the amount of oxidized nicotinamide adenine dinucleotide...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Titov, Denis V., Cracan, Valentin, Goodman, Russell P., Peng, Jun, Grabarek, Zenon, Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850741/
https://ncbi.nlm.nih.gov/pubmed/27124460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad4017
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