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Cell size pleomorphism drives aberrant clone dispersal in proliferating epithelia

As epithelial tissues develop, groups of cells related by descent tend to associate in clonal populations rather than dispersing within the cell layer. While frequently assumed to be a result of differential adhesion, precise mechanisms controlling clonal cohesiveness remain unknown. Here we employ...

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Veröffentlicht in:Dev Cell
Hauptverfasser: Ramanathan, Subramanian P., Krajnc, Matej, Gibson, Matthew C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903429/
https://ncbi.nlm.nih.gov/pubmed/31495693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.08.005
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