Mitophagy protects against statin-mediated skeletal muscle toxicity

The deleterious effects of statins on skeletal muscle are well known, but the mechanism associated with these effects remains unresolved. Statins are associated with mitochondrial damage, which may contribute to muscle myopathy. Here we demonstrate that simvastatin induces mitophagy in skeletal musc...

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Veröffentlicht in:FASEB J
Hauptverfasser: Ramesh, Mridula, Campos, Juliane C., Lee, Pamela, Song, Yang, Hernandez, Genaro, Sin, Jon, Tucker, Kyle C., Saadaeijahromi, Hannaneh, Gurney, Michael, Ferreira, Julio C. B., Andres, Allen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902735/
https://ncbi.nlm.nih.gov/pubmed/31365836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900807RR
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