Mitophagy protects against statin-mediated skeletal muscle toxicity

The deleterious effects of statins on skeletal muscle are well known, but the mechanism associated with these effects remains unresolved. Statins are associated with mitochondrial damage, which may contribute to muscle myopathy. Here we demonstrate that simvastatin induces mitophagy in skeletal musc...

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Bibliographic Details
Published in:FASEB J
Main Authors: Ramesh, Mridula, Campos, Juliane C., Lee, Pamela, Song, Yang, Hernandez, Genaro, Sin, Jon, Tucker, Kyle C., Saadaeijahromi, Hannaneh, Gurney, Michael, Ferreira, Julio C. B., Andres, Allen M.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902735/
https://ncbi.nlm.nih.gov/pubmed/31365836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900807RR
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