Mitophagy Is Required for Acute Cardioprotection by Simvastatin

Aims: We have shown that autophagy and mitophagy are required for preconditioning. While statin's cardioprotective effects are well known, the role of autophagy/mitophagy in statin-mediated cardioprotection is not. In this study, we used HL-1 cardiomyocytes and mice subjected to ischemia/reperf...

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Detalhes bibliográficos
Main Authors: Andres, Allen M., Hernandez, Genaro, Lee, Pamela, Huang, Chengqun, Ratliff, Eric P., Sin, Jon, Thornton, Christine A., Damasco, Marichris V., Gottlieb, Roberta A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208607/
https://ncbi.nlm.nih.gov/pubmed/23901824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5416
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