ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data,...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Lerner, Shaul, Anderzhanova, Elmira, Verbitsky, Sima, Eilam, Raya, Kuperman, Yael, Tsoory, Michael, Kuznetsov, Yuri, Brandis, Alexander, Mehlman, Tevie, Mazkereth, Ram, McCarter, Robert, Segal, Menahem, Nagamani, Sandesh C.S., Chen, Alon, Erez, Ayelet
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902269/
https://ncbi.nlm.nih.gov/pubmed/31747589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.043
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