ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data,...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lerner, Shaul, Anderzhanova, Elmira, Verbitsky, Sima, Eilam, Raya, Kuperman, Yael, Tsoory, Michael, Kuznetsov, Yuri, Brandis, Alexander, Mehlman, Tevie, Mazkereth, Ram, McCarter, Robert, Segal, Menahem, Nagamani, Sandesh C.S., Chen, Alon, Erez, Ayelet
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902269/
https://ncbi.nlm.nih.gov/pubmed/31747589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.043
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