ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data,...

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Pubblicato in:Cell Rep
Autori principali: Lerner, Shaul, Anderzhanova, Elmira, Verbitsky, Sima, Eilam, Raya, Kuperman, Yael, Tsoory, Michael, Kuznetsov, Yuri, Brandis, Alexander, Mehlman, Tevie, Mazkereth, Ram, McCarter, Robert, Segal, Menahem, Nagamani, Sandesh C.S., Chen, Alon, Erez, Ayelet
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902269/
https://ncbi.nlm.nih.gov/pubmed/31747589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.043
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