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A metabolic link between the urea cycle and cancer cell proliferation

Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferati...

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Bibliografski detalji
Izdano u:Mol Cell Oncol
Glavni autori: Nagamani, Sandesh C.S., Erez, Ayelet
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905422/
https://ncbi.nlm.nih.gov/pubmed/27308634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1127314
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