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A metabolic link between the urea cycle and cancer cell proliferation
Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferati...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905422/ https://ncbi.nlm.nih.gov/pubmed/27308634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1127314 |
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