The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

DNA mismatch repair (MMR) maintains genome stability through repair of DNA replication errors. In Escherichia coli, initiation of MMR involves recognition of the mismatch by MutS, recruitment of MutL, activation of endonuclease MutH and DNA strand incision at a hemimethylated GATC site. Here, we stu...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Mardenborough, Yannicka S N, Nitsenko, Katerina, Laffeber, Charlie, Duboc, Camille, Sahin, Enes, Quessada-Vial, Audrey, Winterwerp, Herrie H K, Sixma, Titia K, Kanaar, Roland, Friedhoff, Peter, Strick, Terence R, Lebbink, Joyce H G
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902014/
https://ncbi.nlm.nih.gov/pubmed/31598722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz834
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares