Assessing Chemical-Induced Liver Injury In Vivo From In Vitro Gene Expression Data in the Rat: The Case of Thioacetamide Toxicity

Consumers are exposed to thousands of chemicals with potentially adverse health effects. However, these chemicals will never be tested for toxicity because of the immense resources needed for animal-based (in vivo) toxicological studies. Today, there are no viable in vitro alternatives to these type...

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Bibliographic Details
Published in:Front Genet
Main Authors: Schyman, Patric, Printz, Richard L., Estes, Shanea K., O’Brien, Tracy P., Shiota, Masakazu, Wallqvist, Anders
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901980/
https://ncbi.nlm.nih.gov/pubmed/31850077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01233
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