(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism

Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) retains the rapid and sustained antidepressant-like actions of ketamine, but is spared its dissociative-like properties and abuse potential. While (2R,6R)-HNK is thought to exert its antidepressant-like effects by potentiating α-amin...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Riggs, Lace M., Aracava, Yasco, Zanos, Panos, Fischell, Jonathan, Albuquerque, Edson X., Pereira, Edna F. R., Thompson, Scott M., Gould, Todd D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901515/
https://ncbi.nlm.nih.gov/pubmed/31216563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-019-0443-3
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