Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus

Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome can often yield unintended outcomes. Here, we repo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Goldstein, Jill M., Valido, Austin, Lewandowski, Jordan P., Walker, Ryan G., Mills, Melanie J., Messemer, Kathleen A., Besseling, Paul, Lee, Kyu Ha, Wattrus, Samuel J., Cho, Miook, Lee, Richard T., Wagers, Amy J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901511/
https://ncbi.nlm.nih.gov/pubmed/31819086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54766-y
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg