Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus

Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome can often yield unintended outcomes. Here, we repo...

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Foilsithe in:Sci Rep
Main Authors: Goldstein, Jill M., Valido, Austin, Lewandowski, Jordan P., Walker, Ryan G., Mills, Melanie J., Messemer, Kathleen A., Besseling, Paul, Lee, Kyu Ha, Wattrus, Samuel J., Cho, Miook, Lee, Richard T., Wagers, Amy J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901511/
https://ncbi.nlm.nih.gov/pubmed/31819086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54766-y
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