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Small Molecule Rescue and Glycosidic Conformational Analysis of the Twister Ribozyme

The number of self-cleaving ribozymes has increased sharply in recent years giving rise to elaborations of the four known ribozyme catalytic strategies α, β, γ, and δ. One such extension is utilized by the twister ribozyme, which is hypothesized to conduct δ, or general acid catalysis, via N3 of the...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Messina, Kyle J., Kierzek, Ryszard, Tracey, Matthew A., Bevilacqua, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901379/
https://ncbi.nlm.nih.gov/pubmed/31742390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00742
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