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On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer
G protein–gated inwardly rectifying K(+) (GIRK) channels belong to the inward-rectifier K(+) (Kir) family, are abundantly expressed in the heart and the brain, and require that phosphatidylinositol bisphosphate is present so that intracellular channel-gating regulators such as Gβγ and Na(+) ions can...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6901319/ https://ncbi.nlm.nih.gov/pubmed/31659119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010047 |
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