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G Protein βγ Gating Confers Volatile Anesthetic Inhibition to Kir3 Channels
G protein-activated inwardly rectifying potassium (GIRK or Kir3) channels are directly gated by the βγ subunits of G proteins and contribute to inhibitory neurotransmitter signaling pathways. Paradoxically, volatile anesthetics such as halothane inhibit these channels. We find that neuronal Kir3 cur...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009854/ https://ncbi.nlm.nih.gov/pubmed/21044958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178541 |
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