A Conserved Mechanism for Gating in an Ionotropic Glutamate Receptor

Ionotropic glutamate receptor (iGluR) channels control synaptic activity. The crystallographic structure of GluA2, the prototypical iGluR, reveals a clamshell-like ligand-binding domain (LBD) that closes in the presence of glutamate to open a gate on the pore lining α-helix. How LBD closure leads to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moore, Bryn S., Mirshahi, Uyenlinh L., Ebersole, Tonya L., Mirshahi, Tooraj
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Neurobiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696660/
https://ncbi.nlm.nih.gov/pubmed/23671286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.465187
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