Disrupting the transmembrane domain–mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes

Receptor protein tyrosine phosphatases (RPTPs) play critical regulatory roles in mammalian signal transduction. However, the structural basis for the regulation of their catalytic activity is not fully understood, and RPTPs are generally not therapeutically targetable. This knowledge gap is partiall...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Bloch, Elizabeth, Sikorski, Eden L., Pontoriero, David, Day, Evan K., Berger, Bryan W., Lazzara, Matthew J., Thévenin, Damien
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901304/
https://ncbi.nlm.nih.gov/pubmed/31676686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010229
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