Synthesis of analogs of the Gwt1 inhibitor Manogepix (APX001A) and in vitro evaluation against Cryptococcus spp

Fosmanogepix (APX001) is a first-in-class prodrug molecule that is currently in Phase 2 clinical trials for invasive fungal infections. The active moiety manogepix (APX001A) inhibits the novel fungal protein Gwt1. Gwt1 catalyzes an early step in the GPI anchor biosynthesis pathway. Here we describe...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Trzoss, Michael, Covel, Jonathan A., Kapoor, Mili, Moloney, Molly K., Soltow, Quinlyn A., Webb, Peter J., Shaw, Karen Joy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901109/
https://ncbi.nlm.nih.gov/pubmed/31668974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126713
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