In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical regions, and mortality rates remain high despite current therapies. Here we evaluated the in vitro and in vivo activit...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Shaw, Karen Joy, Schell, Wiley A., Covel, Jonathan, Duboc, Gisele, Giamberardino, C., Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A., Tenor, Jennifer L., Toffaletti, Dena L., Trzoss, Michael, Webb, Peter, Perfect, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105804/
https://ncbi.nlm.nih.gov/pubmed/29891599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00523-18
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