Synthesis of analogs of the Gwt1 inhibitor Manogepix (APX001A) and in vitro evaluation against Cryptococcus spp

Fosmanogepix (APX001) is a first-in-class prodrug molecule that is currently in Phase 2 clinical trials for invasive fungal infections. The active moiety manogepix (APX001A) inhibits the novel fungal protein Gwt1. Gwt1 catalyzes an early step in the GPI anchor biosynthesis pathway. Here we describe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioorg Med Chem Lett
Prif Awduron: Trzoss, Michael, Covel, Jonathan A., Kapoor, Mili, Moloney, Molly K., Soltow, Quinlyn A., Webb, Peter J., Shaw, Karen Joy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901109/
https://ncbi.nlm.nih.gov/pubmed/31668974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126713
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