In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical regions, and mortality rates remain high despite current therapies. Here we evaluated the in vitro and in vivo activit...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Shaw, Karen Joy, Schell, Wiley A., Covel, Jonathan, Duboc, Gisele, Giamberardino, C., Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A., Tenor, Jennifer L., Toffaletti, Dena L., Trzoss, Michael, Webb, Peter, Perfect, John R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105804/
https://ncbi.nlm.nih.gov/pubmed/29891599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00523-18
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